Acromegaly

By Ujala Cygnus

Reviewed by : Jalaz Jain

January 17, 2023

Acromegaly is an endocrine disorder that develops when the pituitary gland is hyperactive and produces excessive growth hormone. This results in increased bone size and height; a condition termed gigantism. However, if it occurs in adulthood, there is no change in height. Instead, facial features, hands and feet appear bigger. This condition is known as acromegaly.

This condition is not so common and progresses slowly. In addition, untreated, high growth hormone levels can affect other parts of the body and the bones leading to life-threatening complications.

Causes

Acromegaly has been associated with pituitary adenoma, a pituitary gland tumour. This tumour induces excessive production of growth hormone. This benign tumour grows slowly, and its effects may not be visible for many years.

Symptoms

The symptoms of acromegaly are:

Enlarged hands and feet

Fatigue and joint or muscle weakness

Pain and limited joint mobility

Enlarged features of the face, such as the lips, nose, facial bones and tongue

Coarse, oily, thickened skin

Excessive sweating and body odour

Vision problems

Small outgrowths of skin tissue (skin tags)

Erectile dysfunction in men

Severe snoring caused by obstruction of the upper airway

Husky voice caused by enlarged vocal cords and sinuses

Headaches, which may be persistent or severe

Menstrual cycle irregularities in women

Loss of interest in sex

Diagnosis

Doctors evaluate the medical history and conduct a physical exam. After this, to confirm the diagnosis and rule out other conditions, they may recommend the following tests:

IGF-1 measurement

Growth hormone suppression test

Imaging modalities such as magnetic resonance imaging help locate and assess the size of a tumour.

Other tests to monitor the condition are:

An echocardiogram to assess heart problems.

Sleep study tests to assess sleep apnea.

A colonoscopy to evaluate the colon.

Treatment

Treatment for acromegaly depends upon the patient’s age and overall health. The treatment options include conventional, surgical and radiation therapy.

Surgery

Surgery is done to remove the tumour that causes excess growth hormone. This modality is quick and effective in lowering growth hormone levels, which can help improve symptoms.

Medication

If surgery does not help manage the condition, medicines may be prescribed to shrink large tumours followed by surgery. Some medicines include:

Somatostatin analogues

GH receptor antagonists

Dopamine agonists

Radiation

Radiation destroys large tumours or sections of tumours that remain after surgery. Alternatively, they help when medicines alone are not effective. For example, radiation helps dramatically decrease levels of growth hormone when administered in multiple 4-6 week sessions. However, a major drawback of radiation therapy is impaired fertility and, rarely, brain injury, vision loss, or secondary tumours.

Prevention

Unfortunately, acromegaly cannot be prevented. This is because the cause of the development of pituitary tumours that cause acromegaly is unclear. However, certain genetic factors may also be involved in causing acromegaly.