A 60-year-old patient with obesity and severe fatty liver disease achieved significant weight loss and improvement in liver health under the treatment and guidance of Dr. Animesh Gupta, Gastroenterologist, Ujala Cygnus Rainbow Hospital, Agra.
Over seven months, the patient achieved a 19.6 kg weight loss, reducing his weight from 110 kg. He also showed a reduction in liver fat, improved liver stiffness, and better lipid profile and liver enzyme levels.
Patient’s Condition
The patient approached Dr. Animesh Gupta with obesity and severe fatty liver disease.
Initial investigations showed:
- Liver fat score (UAP): 316 dB/m
- Liver stiffness: 7.6 kPa
- Associated concerns: Increased risk of progressive liver disease, diabetes and cardiovascular complications.
After evaluating the patient’s condition, Dr. Gupta planned a comprehensive treatment approach to address obesity and improve metabolic and liver health.
Treatment Approach: Two Therapies, One Comprehensive Plan
In April, under the supervision of Dr. Animesh Gupta, the patient began a combination of two treatments:
1. Spatz Adjustable Intragastric Balloon
An adjustable intragastric balloon was placed endoscopically under short anaesthesia, without surgery or incisions. The balloon occupied space in the stomach, helping the patient feel full sooner and supporting portion control.
Its volume was gradually increased from 350 ml to 480 ml as the patient adapted to the treatment.
2. Tirzepatide Therapy
Alongside the balloon procedure, the patient was started on once-weekly tirzepatide injections. The dose was gradually increased every month to the current dose of 10 mg.
The medication works through GIP and GLP-1 hormone pathways, helping regulate appetite and improve metabolic health.
Results After Seven Months
Under Dr. Gupta’s continued medical supervision, the combined treatment approach resulted in measurable improvements in the patient’s weight, liver health and lipid profile.
| Health Parameter | Before Treatment | After Treatment |
| Weight | 110kg | 90.4 kg (19.6 kg reduction in seven months) |
| Liver fat score (UAP) | 316 dB/m | 247 dB/m |
| Liver stiffness | 7.6 kPa | 4.4 kPa |
| Triglycerides | 160mg/dl | 114 (Reduced by 29%) |
| Non-HDL cholesterol | 151 | 131 (Reduced by 13%) |
Additional clinical observations:
- Liver fat reduced from the severe range to just above the normal cut-off.
- Liver stiffness returned to the normal range.
- Liver enzymes (AST, ALT and GGT) were within normal limits.
- The stomach lining remained healthy at the time of balloon removal, with no erosions or ulcers.
Continued Care and Follow-Up
On 6 November, after seven months of treatment, Dr. Animesh Gupta successfully removed the adjustable intragastric balloon.
The patient continues tirzepatide therapy along with dietary guidance and lifestyle follow-up to help maintain the weight loss and prevent weight regain.
Dr. Gupta’s treatment approach focuses not only on achieving weight reduction but also on sustaining long-term improvements in metabolic and liver health.
A Step Towards Better Liver Health
This case highlights how a carefully planned combination of endoscopic intervention, medication, dietary changes and lifestyle management can support meaningful improvements in patients with obesity and fatty liver disease.
The patient’s discipline and commitment throughout the seven-month treatment journey, along with specialist guidance from Dr. Animesh Gupta, Gastroenterologist, played an important role in achieving these outcomes.